2022
Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe
Garcia-Souto D, Bruzos AL, Diaz S, Rocha S, Pequeño-Valtierra A, Roman-Lewis CF, Alonso J, Rodriguez R, Costas D, Rodriguez-Castro J, Villanueva A, Silva L, Valencia JM, Annona G, Tarallo A, Ricardo F, Bratoš Cetinić A, Posada D, Pasantes JJ, Tubio JM
Elife, 11:e66946 (2022). DOI: 10.7554/eLife.66946
PanCancer analysis of somatic mutations in repetitive regions reveals recurrent mutations in snRNA U2
Bousquets-Muñoz P, Díaz-Navarro A, Nadeu F, Sánchez-Pitiot A, López-Tamargo S, Shuai S, Balbín M, Tubio JMC, Beà S, Martin-Subero JI, Gutiérrez-Fernández A, Stein LD, Campo E, Puente XS
NPJ Genomic Medicine, 7:19 (2022). DOI: 10.1038/s41525-022-00292-2
Clinical significance of baseline Pan-Immune-Inflammation Value and its dynamics in metastatic colorectal cancer patients under first-line chemotherapy
Pérez-Martelo M, González-García A, Vidal-Ínsua Y, Blanco-Freire C, Brozos-Vázquez EM, Abdulkader-Nallib I, Álvarez-Fernández J, Lázare-Iglesias H, García-Martínez C, Betancor YZ, Sánchez-Ares M, Tubío JMC, Vázquez-Rivera F, Candamio-Folgar S, López-López R, Ruiz-Bañobre J
Scientific Reports, 12:6893 (2022). DOI: 10.1038/s41598-022-10884-8
Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21
Pena-Leon V, Folgueira C, Barja-Fernández S, Pérez-Lois R, Da Silva Lima N, Martin M, Heras V, Martinez-Martinez S, Valero P, Iglesias C, Duquenne M, Al-Massadi O, Beiroa D, Souto Y, Fidalgo M, Sowmyalakshmi R, Guallar D, Cunarro J, Castelao C, Senra A, González-Saenz P, Vázquez-Cobela R, Leis R, Sabio G, Mueller-Fielitz H, Schwaninger M, López M, Tovar S, Casanueva FF, Valjent E, Diéguez C, Prevot V, Nogueiras R, Seoane LM
Nature Metabolism (2022). DOI: 10.1038/s42255-022-00602-z
A TET1-PSPC1-Neat1 molecular axis modulates PRC2 functions in controlling stem cell bivalency
Huang X, Bashkenova N, Hong Y, Lyu C, Guallar D, Hu Z, Malik V, Li D, Wang H, Shen X, Zhou H, Wang J
Cell Reports (2022).
Glial Bmal1 role in mammalian retina daily changes
Serena Riccitelli, Fabio Boi, Davide Lonardoni, Lidia Giantomasi, Olga Barca-Mayo, Davide De Pietri Tonelli, Silvia Bisti, Stefano Di Marco & Luca Berdondini
Scientific Reports, 21561 (2022). DOI: 10.1038/s41598-022-25783-1
Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis
Eva Rial-Pensado, Verónica Rivas-Limeres, Carmen Grijota-Martínez, Amanda Rodríguez-Díaz, Valentina Capelli, Olga Barca-Mayo, Rubén Nogueiras, Jens Mittag, Carlos Diéguez, Miguel López
Frontiers in Physiology, 13:1017381 (2022). DOI: 10.1038/s41598-022-25783-1
Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function
da Silva Lima N, Fondevila MF, Nóvoa E, Buqué X, Mercado-Gómez M, Gallet S, González-Rellan MJ, Fernandez U, Loyens A, Garcia-Vence M, Chantada-Vazquez MDP, Bravo SB, Marañon P, Senra A, Escudero A, Leiva M, Guallar D, Fidalgo M, Gomes P, Claret M, Sabio G, Varela-Rey M, Delgado TC, Montero-Vallejo R, Ampuero J, López M, Diéguez C, Herrero L, Serra D, Schwaninger M, Prevot V, Gallego-Duran R, Romero-Gomez M, Iruzubieta P, Crespo J, Martinez-Chantar ML, Garcia-Monzon C, Gonzalez-Rodriguez A, Aspichueta P, Nogueiras R
Journal of Hepatology (2022). DOI: 10.1016/j.jhep.2021.09.008
Microglial angiotensin type 2 receptors mediate sex-specific expression of inflammatory cytokines independently of circulating estrogen
Garrido-Gil, Pablo; Pedrosa, Maria A.; Garcia-Garrote, Maria; Pequeño-Valtierra, Ana; Rodríguez-Castro, Jorge; García-Souto, Daniel; Rodríguez-Pérez, Ana I.; Rodríguez-Pérez A.I.; Labandeira-Garcia, Jose L
Glia (2022). DOI: 10.1002/glia.24255
Molecular data confirms the existence of distinct lineages within Lumbricus friendi (Cognetti 1904) and related “friends”
Briones M.J.I, García-Souto D, Galindo J, Morán P, Keith A, Schmidt O
European Journal of Soil Biology (2022). DOI: 10.1016/j.ejsobi.2021.103382
2021
Haplotype-resolved diverse human genomes and integrated analysis of structural variation
Ebert P*, Audano PA*, Zhu Q*, Rodriguez-Martin B*, Porubsky D, Bonder MJ, Sulovari A, Ebler J, Zhou W, Serra Mari R, Yilmaz F, Zhao X, Hsieh P, Lee J, Kumar S, Lin J, Rausch T, Chen Y, Ren J, Santamarina M, Höps W, Ashraf H, Chuang NT, Yang X, Munson KM, Lewis AP, Fairley S, Tallon LJ, Clarke WE, Basile AO, Byrska-Bishop M, Corvelo A, Evani US, Lu TY, Chaisson MJP, Chen J, Li C, Brand H, Wenger AM, Ghareghani M, Harvey WT, Raeder B, Hasenfeld P, Regier AA, Abel HJ, Hall IM, Flicek P, Stegle O, Gerstein MB, Tubio JMC, Mu Z, Li YI, Shi X, Hastie AR, Ye K, Chong Z, Sanders AD, Zody MC, Talkowski ME, Mills RE, Devine SE, Lee C, Korbel JO, Marschall T, Eichler EE
Science, 372:eabf7117 (2021). DOI: 10.1126/science.abf7117
Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture
Álvarez EG, Demeulemeester J, Otero P, Jolly C, García-Souto D, Pequeño-Valtierra A, Zamora J, Tojo M, Temes J, Baez-Ortega A, Rodriguez-Martin B, Oitaben A, Bruzos AL, Martínez-Fernández M, Haase K, Zumalave S, Abal R, Rodríguez-Castro J, Rodriguez-Casanova A, Diaz-Lagares A, Li Y, Raine KM, Butler AP, Otero I, Ono A, Aikata H, Chayama K, Ueno M, Hayami S, Yamaue H, Maejima K, Blanco MG, Forns X, Rivas C, Ruiz-Bañobre J, Pérez-Del-Pulgar S, Torres-Ruiz R, Rodriguez-Perales S, Garaigorta U, Campbell PJ, Nakagawa H, Van Loo P, Tubio JMC
Nature Communications, 12:6910 (2021). DOI: 10.1038/s41467-021-26805-8
Subclone Eradication Analysis Identifies Targets for Enhanced Cancer Therapy and Reveals L1 Retrotransposition as a Dynamic Source of Cancer Heterogeneity
Ketola K, Kaljunen H, Taavitsainen S, Kaarijärvi R, Järvelä E, Rodríguez-Martín B, Haase K, Woodcock DJ, Tubio J, Wedge DC, Nykter M, Bova GS
Cancer Research, 81:4901-4909 (2021). DOI: 10.1158/0008-5472.CAN-21-0371
CDKN2A deletion is a frequent event associated with poor outcome in patients with peripheral T-cell lymphoma not otherwise specified (PTCL-NOS)
Maura F, Dodero A, Carniti C, Bolli N, Magni M, Monti V, Cabras A, Leongamornlert D, Abascal F, Diamond B, Rodriguez-Martin B, Zamora J, Butler A, Martincorena I, Tubio JMC, Campbell PJ, Chiappella A, Pruneri G, Corradini P
Haematologica, 106:2918-2926 (2021). DOI: 10.3324/haematol.2020.262659
Astrocyte clocks and glucose homeostasis (Review)
Olga Barca-Mayo, Miguel López
Frontiers in Endocrinology, 12:662017 (2021). DOI: 10.3389/fendo.2021.662017
O-GlcNAcylated p53 in the liver modulates hepatic glucose production
Maria J Gonzalez-Rellan, Marcos F Fondevila, Uxia Fernandez, Amaia Rodríguez, Marta Varela-Rey, Christelle Veyrat-Durebex, Samuel Seoane, Ganeko Bernardo, Fernando Lopitz-Otsoa, David Fernández-Ramos, Jon Bilbao, Cristina Iglesias, Eva Novoa, Cristina Ameneiro, Ana Senra, Daniel Beiroa, Juan Cuñarro, Maria Dp Chantada-Vazquez, Maria Garcia-Vence, Susana B Bravo, Natalia Da Silva Lima, Begoña Porteiro, Carmen Carneiro, Anxo Vidal, Sulay Tovar, Timo D Müller, Johan Ferno, Diana Guallar, Miguel Fidalgo, Guadalupe Sabio, Stephan Herzig, Won Ho Yang, Jin Won Cho, Maria Luz Martinez-Chantar, Roman Perez-Fernandez, Miguel López, Carlos Dieguez, Jose M Mato, Oscar Millet, Roberto Coppari Ashwin Woodhoo, Gema Fruhbeck, Ruben Nogueiras
Nature Communications, 12:662017 (2021). DOI: 10.1038/s41467-021-25390-0
Phase separation of OCT4 controls TAD reorganization to promote cell fate transitions
Wang J, Yu H, Ma Q, Zeng P, Wu D, Hou Y, Liu X, Jia L, Sun J, Chen Y, Guallar D, Fidalgo M, Chen J, Yu Y, Jiang S, Li F, Zhao C, Huang X, Wang J, Li C, Sun Y, Zeng X, Zhang W, Miao Y, Ding J
Cell Stem Cell (2021). DOI: 10.1016/j.stem.2021.04.023
The complexity of TET2 functions in Pluripotency and Development
Garcia-Outeiral V, de la Parte C, Fidalgo M, Guallar D
Frontiers in Cell and Developmental Biology (2021). DOI: 10.3389/fcell.2020.630754
The L-α-Lysophosphatidylinositol/G Protein-Coupled Receptor 55 System Induces the Development of Nonalcoholic Steatosis and Steatohepatitis
Fondevila MF, Fernandez U, Gonzalez-Rellan MJ, Da Silva Lima N, Buque X, Gonzalez-Rodriguez A, Alonso C, Iruarrizaga-Lejarreta M, Delgado TC, Varela-Rey M, Senra A, Garcia-Outeiral V, Novoa E, Iglesias C, Porteiro B, Beiroa D, Folgueira C, Tojo M, Torres JL, Hernández-Cosido L, Blanco Ó, Arab JP, Barrera F, Guallar D, Fidalgo M, López M, Dieguez C, Marcos M, Martinez-Chantar ML, Arrese M, Garcia-Monzon C, Mato JM, Aspichueta P, Nogueiras R
Hepatology (2021). DOI: 10.1002/hep.31290
The L-α-Lysophosphatidylinositol/G Protein-Coupled Receptor 55 System Induces the Development of Nonalcoholic Steatosis and Steatohepatitis
Fondevila MF, Fernandez U, Gonzalez-Rellan MJ, Da Silva Lima N, Buque X, Gonzalez-Rodriguez A, Alonso C, Iruarrizaga-Lejarreta M, Delgado TC, Varela-Rey M, Senra A, Garcia-Outeiral V, Novoa E, Iglesias C, Porteiro B, Beiroa D, Folgueira C, Tojo M, Torres JL, Hernández-Cosido L, Blanco Ó, Arab JP, Barrera F, Guallar D, Fidalgo M, López M, Dieguez C, Marcos M, Martinez-Chantar ML, Arrese M, Garcia-Monzon C, Mato JM, Aspichueta P, Nogueiras R
Hepatology (2021). DOI: 10.1002/hep.31290
Satellitome analysis of the pacific oyster crassostrea gigas reveals new pattern of satellite dna organization, highly scattered across the genome
Tunjić-Cvitanić, Monika; Pasantes, Juan J.; García-Souto, Daniel; Cvitanić, Tonči; Plohl, Miroslav
International Journal of Molecular Sciences (2021). DOI: 10.3390/ijms22136798
2020
Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition
Rodriguez-Martin B, Alvarez EG, Baez-Ortega A, Zamora J, Supek F, Demeulemeester J, Santamarina M, Ju YS, Temes J, Garcia-Souto D, Detering H, Li Y, Rodriguez-Castro J, Dueso-Barroso A, Bruzos AL, Dentro SC, Blanco MG, Contino G, Ardeljan D, Tojo M, Roberts ND, Zumalave S, Edwards PA, Weischenfeldt J, Puiggròs M, Chong Z, Chen K, Lee EA, Wala JA, Raine KM, Butler A, Waszak SM, Navarro FCP, Schumacher SE, Monlong J, Maura F, Bolli N, Bourque G, Gerstein M, Park PJ, Wedge DC, Beroukhim R, Torrents D, Korbel JO, Martincorena I, Fitzgerald RC, Van Loo P, Kazazian HH, Burns KH; PCAWG Structural Variation Working Group; Campbell PJ, Tubio JMC
Nature Genetics, 52:306-319 (2020). DOI: 10.1038/s41588-019-0562-0
Pan-Cancer analysis of whole genomes
The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium
Nature, 578:82-93 (2020). DOI: 10.1038/s41586-020-1969-6
ADAR1-Dependent RNA Editing Promotes MET and iPSC Reprogramming by Alleviating ER Stress
Diana Guallar*¥, Alejandro Fuentes-Iglesias*, Yara Souto, Cristina Ameneiro, Oscar Freire-Agulleiro, Jose Angel Pardavila, Adriana Escudero, Vera Garcia-Outeiral, Tiago Moreira, Carmen Saenz, Heng Xiong, Dongbing Liu, Shidi Xiao, Yong Hou, Kui Wu, Daniel Torrecilla, Jochen C Hartner, Miguel G Blanco, Leo J Lee; Miguel Lopez, Carl R Walkley, Jianong Wang.¥, Miguel Fidalgo¥
Cell Stem Cell (2020). DOI: 10.1016/j.stem.2020.04.016
Extensive heterogeneity in somatic mutation and selection in the human bladder
Lawson ARJ, Abascal F, Coorens THH, Hooks Y, O'Neill L, Latimer C, Raine K, Sanders MA, Warren AY, Mahbubani KTA, Bareham B, Butler TM, Harvey LMR, Cagan A, Menzies A, Moore L, Colquhoun AJ, Turner W, Thomas B, Gnanapragasam V, Williams N, Rassl DM, Vöhringer H, Zumalave S, Nangalia J, Tubío JMC, Gerstung M, Saeb- Parsy K, Stratton MR, Campbell PJ, Mitchell TJ, Martincorena I
Science, 370:75-82 (2020). DOI: 10.1126/science.aba8347
Analysis of non-coding somatic drivers in 2,658 cancer whole genomes
Rheinbay E, Nielsen MM, Abascal F, Wala JA, Shapira O, Tiao G, Hornshøj H, Hess JM, Juul RI, Lin Z, Feuerbach L, Sabarinathan R, Madsen T, Kim J, Mularoni L, Shuai S, Lanzós A, Herrmann C, Maruvka YE, Shen C, Amin SB, Bandopadhayay P, Bertl J, Boroevich KA, Busanovich J, Carlevaro-Fita J, Chakravarty D, Chan CWY, Craft D, Dhingra P, Diamanti K, Fonseca NA, Gonzalez-Perez A, Guo Q, Hamilton MP, Haradhvala NJ, Hong C, Isaev K, Johnson TA, Juul M, Kahles A, Kahraman A, Kim Y, Komorowski J, Kumar K, Kumar S, Lee D, Lehmann KV, Li Y, Liu EM, Lochovsky L, Park K, Pich O, Roberts ND, Saksena G, Schumacher SE, Sidiropoulos N, Sieverling L, Sinnott-Armstrong N, Stewart C, Tamborero D, Tubio JMC, Umer HM, Uusküla-Reimand L, Wadelius C, Wadi L, Yao X, Zhang CZ, Zhang J, Haber JE, Hobolth A, Imielinski M, Kellis M, Lawrence MS, von Mering C, Nakagawa H, Raphael BJ, Rubin MA, Sander C, Stein LD, Stuart JM, Tsunoda T, Wheeler DA, Johnson R, Reimand J, Gerstein M, Khurana E, Campbell PJ, López-Bigas N; PCAWG Drivers and Functional Interpretation Working Group; PCAWG Structural Variation Working Group; Weischenfeldt J, Beroukhim R, Martincorena I, Pedersen JS, Getz G
Nature, 578:102-1 (2020). DOI: 10.1038/s41586-020-1965-x
VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma
Lorenzo-Martín LF, Fernández-Parejo N, Menacho-Márquez M, Rodríguez-Fdez S, Robles-Valero J, Zumalave S, Fabbiano S, Pascual G, García-Pedrero JM, Abad A, García-Macías MC, González N, Lorenzano-Menna P, Pavón MA, González-Sarmiento R, Segrelles C, Paramio JM, Tubío JMC, Rodrigo JP, Benitah SA, Cuadrado M, Bustelo XR
Nature Communications, 11:4788 (2020). DOI: 10.1038/s41467-020-18524-3
LC–MS/MS analysis of twelve neurotransmitters and amino acids in mouse cerebrospinal fluid
Blanco ME, Barca-Mayo O, Bandiera T, Tonelli DDP, Armirotti A
Journal of Neuroscience Methods, 41:108760 (2020). DOI: 10.1016/j.jneumeth.2020.108760
GAD-alum immunotherapy in type 1 diabetes expands bifunctional Th1/Th2 autoreactive CD4 T cells
Sefina Arif, Iria Gomez-Tourino, Yogesh Kamra, Irma Pujol Autonell, Emily Hanton, Timothy Tree, Daisy Melandri, Caroline Hull, Diane K Wherrett, Craig Beam, Bart Roep, Anna Lorenc, Mark Peakman
Diabetologia (2020). DOI: 10.1007/s00125-020-05130-7
Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation
Lan J, Rajan N, Bizet M, Penning A, Singh NK, Guallar D, Calonne E, Li Greci A, Bonvin E, Deplus R, Hsu PJ, Nachtergaele S, Ma C, Song R, Fuentes-Iglesias A, Hassabi B, Putmans P, Mies F, Menschaert G, Wong JJL, Wang J, Fidalgo M, Yuan B, Fuks F
Nature Communications (2020). DOI: 10.1038/s41467-020-18729-6
BMAL1 coordinates energy metabolism and differentiation of pluripotent stem cells
Ameneiro C, Moreira T, Fuentes-Iglesias A, Coego A, Garcia-Outeiral V, Escudero A, Torrecilla D, Mulero-Navarro S, Carvajal-Gonzalez JM, Guallar D, Fidalgo M
Life Science Alliance (2020). DOI: 10.26508/lsa.201900534
Sequence Composition Underlying Centromeric and Heterochromatic Genome Compartments of the Pacific Oyster Crassostrea gigas
Cvitanić, Monika Tunjić; Zeljko, Tanja Vojvoda; Pasantes, Juan J.; García-Souto, Daniel; Gržan, Tena; Despot- Slade, Evelin; Plohl, Miroslav; Šatović, Eva
Genes (2020). DOI: 10.3390/genes11060695
