‘We use multiomics and cutting-edge computational methods to understand the molecular mechanisms, and physiological and evolutionary processes involved in disease, development and aging, and their relationship with the environment.’’
Research lines
• Cancer genomics (leader: Jose Tubio)
We study the impact of the activity of transposable elements and viruses on the structure and function of the tumor genome, and how these changes influence the origin and evolution of cancer.
• Molecular cytogenetics and disease (leader: Daniel Garcia-Souto)
We use alternative approaches based on molecular cytogenetics to understand the role of chromosomal instability in disease and cancer.
• Autoimmunity (leader: Iria Gomez)
This line focuses on understanding the molecular mechanisms of autoimmunity and how small molecules can influence both its development and its regulation. We seek to identify new T cell epitopes and T cell receptor characteristics in the context of autoimmunity.
• Epigenetics and gene regulation (leader: Diana Guallar)
We investigate how epigenetics and epitranscriptomics cooperate to regulate cellular function. We focus on understanding how the loss of these regulatory layers contributes to aging and age-related diseases.
• Circadian rhythms and physiology (leader: Olga Barca)
This line is dedicated to the study of circadian rhythms and their impact on neurodegeneration, metabolism (obesity and diabetes) and aging. Various molecular and cellular biology techniques are used, including transcriptomics and proteomics, to in vivo studies in genetically modified animal models.
• Genetics and evolution (leader: Carlos Garcia)
This line covers different areas, from quantitative genetics to evolutionary genetics, applied to studying the evolutionary mechanisms that direct the origin and progression of some genetic diseases, such as cancer, neurodegenerative diseases or rare diseases.
